List of Publications

Publications in Scientific Journals

  1. P. D. Fischer, E. Papadopoulos, J. M. Dempersmier, Z.-F. Wang, R. P. Nowak, K. A. Donovan, J. Kalabathula, C. Gorgulla, P. P. M. Junghanns, E. Kabha, N. Dimitrakakis, O. I. Petrov, C. Mitsiades, C. Ducho, V. Gelev, E. S. Fischer, G. Wagner, H. Arthanari; A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders; Eur. J. Med. Chem. 2021, 219, 113435.
  2. K. Voos, E. Schönauer, A. Alhayek, J. Haupenthal, A. Andreas, R. Müller, R. W. Hartmann, H. Brandstetter, A. K. H. Hirsch, C. Ducho; Phosphonate as Stable Zinc-binding Group for Inhibitors of Clostridial Collagenase H (ColH) as Pathoblocker Agents; ChemMedChem 2021, 16, 1257-1267. (selected as 'Very Important Paper (VIP)', Front Cover)
  3. M. Hawner, C. Ducho; Cellular Targeting of Oligonucleotides by Conjugation with Small Molecules; Molecules 2020, 25, 5963. (Review)
  4. G. Niro, S. C. Weck, C. Ducho; Merging Natural Products: Muraymycin-Sansanmycin Hybrid Structures as Novel Scaffold for Potential Antibacterial Agents; Chem. Eur. J. 2020, 26, 16875-16887.
  5. M. Wojtyniak, B. Schmidtgall, P. Kirsch, C. Ducho; Towards Zwitterionic Oligonucleotides with Improved Properties: the NAA/LNA‐Gapmer Approach; ChemBioChem 2020, 21, 3234-3243. (Cover Feature)
  6. Z. Cui, J. Overbay, X. Wang, X. Liu, Y. Zhang, M. Bhardwaj, A. Lemke, D. Wiegmann, G. Niro, J. S. Thorson, C. Ducho, S. G. Van Lanen; Pyridoxal-5'-phosphate-dependent alkyl transfer in nucleoside antibiotic biosynthesis; Nat. Chem. Biol. 2020, 16, 904-911.
  7. K. Leyerer, S. Koppermann, C. Ducho; Unexpected Seven-Membered Ring Formation for Muraymycin-Type Nucleoside-Peptide Antibiotics; Molbank 2020, 2020, M1122.
  8. A. Saady, M. Wojtyniak, E. Varon, V. Böttner, N. Kinor, Y. Shav-Tal, C. Ducho, B. Fischer; Specific, Sensitive, and Quantitative Detection of HER-2 mRNA Breast Cancer Marker by Fluorescent Light-Up Hybridization Probes; Bioconjugate Chem. 2020, 31, 1188-1198.
  9. A. Saady, N. Steinman, M. Wojtyniak, C. Ducho, B. Fischer; Synthesis of 2'‑deoxyuridine modified with 3,5-difluoro-4-methoxybenzylidene imidazolinone (DFMBI) derivative for incorporation into oligonucleotide probes for detection of HER2 breast cancer marker; Curr. Protoc. Nucleic Acid Chem. 2020, 80, e104.
  10. A. Heib, G. Niro, S. Weck, S. Koppermann, C. Ducho; Muraymycin Nucleoside Antibiotics: Structure-Activity Relationship for Variations in the Nucleoside Unit; Molecules 2020, 25, 22.
  11. K. Leyerer, S. Koppermann, C. Ducho; Solid Phase-Supported Synthesis of Muraymycin Analogues; Eur. J. Org. Chem. 2019, 7420-7431. (Front Cover)
  12. A. Saady, V. Böttner, M. Meng, E. Varon, Y. Shav-Tal, C. Ducho, B. Fischer; An oligonucleotide probe incorporating the chromophore of green fluorescent protein is useful for the detection of HER-2 mRNA breast cancer marker; Eur. J. Med. Chem. 2019, 173, 99-106.
  13. R. Linder, C. Ducho; Unified Synthesis of Densely Functionalized Amino Acid Building Blocks for the Preparation of Caprazamycin Nucleoside Antibiotics; Eur. J. Org. Chem. 2019, 1523-1534.
  14. D. Wiegmann, S. Koppermann, C. Ducho; Aminoribosylated Analogues of Muraymycin Nucleoside Antibiotics; Molecules 2018, 23, 3085.
  15. M. Meng, B. Schmidtgall, C. Ducho; Enhanced Stability of DNA Oligonucleotides with Partially Zwitterionic Backbone Structures in Biological Media; Molecules 2018, 23, 2941.
  16. A. P. Spork, S. Koppermann, S. Schier (née Wohnig), R. Linder, C. Ducho; Analogues of Muraymycin Nucleoside Antibiotics with Epimeric Uridine-Derived Core Structures; Molecules 2018, 23, 2868.
  17. Z. Cui, X. Liu, J. Overbay, W. Cai, X. Wang, A. Lemke, D. Wiegmann, G. Niro, J. S. Thorson, C. Ducho, S. G. Van Lanen; Enzymatic Synthesis of the Ribosylated Glycyl-Uridine Disaccharide Core of Peptidyl Nucleoside Antibiotics; J. Org. Chem. 2018, 83, 7239-7249.
  18. Z. Cui, X.-C. Wang, X. Liu, A. Lemke, S. Koppermann, C. Ducho, J. Rohr, J. S. Thorson, S. G. Van Lanen; Self-Resistance During Muraymycin Biosynthesis: A Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order; Antimicrob. Agents Chemother. 2018, 62, e00193-18.
  19. M. Meng, C. Ducho; Oligonucleotide analogues with cationic backbone linkages; Beilstein J. Org. Chem. 2018, 14, 1293-1308. (Review)
  20. Z. Cui, X. Wang, S. Koppermann, J. S. Thorson, C. Ducho, S. G. Van Lanen; Antibacterial Muraymycins from Mutant Strains of Streptomyces sp. NRRL 30471; J. Nat. Prod. 2018, 81, 942-948.
  21. L. Elsharkawy, R. El-Sakhawy, M. Abdel-Halim, K. Lee, G. Piazza, C. Ducho, R. W. Hartmann, A. Abadi; Design and Synthesis of Novel Annulated Thienopyrimidines as Phosphodiesterase 5 (PDE5) Inhibitors; Arch. Pharm. Chem. Life Sci. 2018, 351, e1800018.
  22. S. Koppermann, Z. Cui, P. D. Fischer, X. Wang, J. Ludwig, J. S. Thorson, S. G. Van Lanen, C. Ducho; Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics; ChemMedChem 2018, 13, 779-784. (Cover feature)
  23. Y. Huang, X. Liu, Z. Cui, D. Wiegmann, G. Niro, C. Ducho, Y. Song, Z. Yang, S. G. Van Lanen; Pyridoxal-5'-phosphate as an oxygenase cofactor: Discovery of a carboxamide-forming, α-amino acid monooxygenase-decarboxylase; Proc. Natl. Acad. Sci. USA 2018, 115, 974-979.
  24. D. Wiegmann, A. P. Spork, G. Niro, C. Ducho; Ribosylation of an Acid-Labile Glycosyl Acceptor as a Potential Key Step for the Synthesis of Nucleoside Antibiotics; Synlett 2018, 29, 440-446.
  25. B. Schmidtgall, A. Kuepper, M. Meng, T. N. Grossmann, C. Ducho; Oligonucleotides with Cationic Backbone and Their Hybridization with DNA: Interplay of Base Pairing and Electrostatic Attraction; Chem. Eur. J. 2018, 24, 1544-1553. (selected as 'Hot Paper')
  26. E. Schönauer, A. M. Kany, J. Haupenthal, K. Hüsecken, I. J. Hoppe, K. Voos, S. Yahiaoui, B. Elsässer, C. Ducho, H. Brandstetter, R. W. Hartmann; Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases; J. Am. Chem. Soc. 2017, 139, 12696-12703.
  27. S. Wohnig, A. P. Spork, S. Koppermann, G. Mieskes, N. Gisch, R. Jahn, C. Ducho; Total Synthesis of Dansylated Park's Nucleotide for High-Throughput MraY Assays; Chem. Eur. J. 2016, 22, 17813-17819.
  28. F. Gräf, B. Vukosavljevic, J.-P. Michel, M. Wirth, O. Ries, C. De Rossi, M. Windbergs, V. Rosilio, C. Ducho, S. Gordon, C.-M. Lehr; The bacterial cell envelope as delimiter of anti-infective bioavailability - An in vitro permeation model of the Gram-negative bacterial inner membrane; J. Controlled Release 2016, 243, 214-224.
  29. S. Koppermann, C. Ducho; Naturstoffe bei der Arbeit: strukturelle Einblicke in die Inhibition des bakteriellen Membranproteins MraY; Angew. Chem. 2016, 128, 11896-11898; Natural Products at Work: Structural Insights into Inhibition of the Bacterial Membrane Protein MraY; Angew. Chem. Int. Ed. 2016, 55, 11722-11724. (Highlight article)
  30. D. Wiegmann, S. Koppermann, M. Wirth, G. Niro, K. Leyerer, C. Ducho; Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents; Beilstein J. Org. Chem. 2016, 12, 769-795. (Review)
  31. A. Lemke, C. Ducho; Synthesis of Deuterium-Labelled 3-Hydroxy-L-arginine: Comparative Studies on Different Protecting-Group Strategies; Eur. J. Org. Chem. 2016, 87-98.
  32. C. Ducho; Enzymatically Cleavable siRNA Prodrugs: a New Paradigm for the Intracellular Delivery of RNA-Based Therapeutics; ChemMedChem 2015, 10, 1625-1627. (Highlight article)
  33. W. Cai, A. Goswami, Z. Yang, X. Liu, K. D. Green, S. Barnard-Britson, S. Baba, M. Funabashi, K. Nonaka, M. Sunkara, A. J. Morris, A. P. Spork, C. Ducho, S. Garneau-Tsodikova, J. S. Thorson, S. G. Van Lanen; The Biosynthesis of Capuramycin-Type Antibiotics: Identification of the A-102395 Biosynthetic Gene Cluster, Mechanism of Self-Resistance, and Formation of Uridine-5'-Carboxamide; J. Biol. Chem. 2015, 290, 13710-13724.
  34. O. Ries, C. Carnarius, C. Steinem, C. Ducho; Membrane-interacting properties of the functionalised fatty acid moiety of muraymycin antibiotics; Med. Chem. Commun. 2015, 6, 879-886.
  35. B. Schmidtgall, C. Höbartner, C. Ducho; NAA-modified DNA oligonucleotides with zwitterionic backbones: stereoselective synthesis of A-T phosphoramidite building blocks; Beilstein J. Org. Chem. 2015, 11, 50-60.
  36. B. Schmidtgall, A. P. Spork, F. Wachowius, C. Höbartner, C. Ducho; Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure; Chem. Commun. 2014, 50, 13742-13745.
  37. M. T. Rodolisa, A. Mihalyi, C. Ducho, K. Eitel, B. Gust, R. J. M. Goss, T. D. H. Bugg; Mechanism of action of the uridyl peptide antibiotics: an unexpected link to a protein-protein interaction site in translocase MraY; Chem. Commun. 2014, 50, 13023-13025.
  38. A. P. Spork, M. Büschleb, O. Ries, D. Wiegmann, S. Boettcher, A. Mihalyi, T. D. H. Bugg, C. Ducho; Lead Structures for New Antibacterials: Stereocontrolled Synthesis of a Bioactive Muraymycin Analogue; Chem. Eur. J. 2014, 20, 15292-15297.
  39. O. Ries, M. Büschleb, M. Granitzka, D. Stalke, C. Ducho; Amino acid motifs in natural products: synthesis of O-acylated derivatives of (2S,3S)-3-hydroxyleucine; Beilstein J. Org. Chem. 2014, 10, 1135-1142.
  40. M. Funabashi, S. Baba, T. Takatsu, M. Kizuka, Y. Ohata, M. Tanaka, K. Nonaka, A. P. Spork, C. Ducho, W.-C. L. Chen, S. G. Van Lanen; Structure-Based Gene Targeting Discovery of Sphaerimicin, a Bacterial Translocase I Inhibitor; Angew. Chem. 2013, 125, 11821-11825; Angew. Chem. Int. Ed. 2013, 52, 11607-11611.
  41. A. P. Spork, C. Ducho; Stereocontrolled Synthesis of 5'- and 6'-Epimeric Analogues of Muraymycin Nucleoside Antibiotics; Synlett 2013, 24, 343-346.
  42. W. Meiser, M. Buback, O. Ries, C. Ducho, A. Sidoruk; EPR-Study into cross-termination and fragmentation of the RAFT model system phenylethyl-phenylethyl dithiobenzoate; Macromol. Chem. Phys. 2013, 214, 924-933.
  43. O. Ries, M. Granitzka, D. Stalke, C. Ducho; Concise Synthesis and X-ray Crystal Structure of N-Benzyl-2-(pyrimidin-4'-ylamino)-thiazole-4-carboxamide ('Thiazovivin'), a Small-Molecule Tool for Stem Cell Research; Synth. Commun. 2013, 43, 2876-2882.
  44. R. B. Hamed, J. R. Gomez-Castellanos, L. Henry, C. Ducho, M. A. McDonough, C. J. Schofield; The enzymes of β-lactam biosynthesis; Nat. Prod. Rep. 2013, 30, 21-107. (Review, front cover)
  45. S. Barnard-Britson, X. Chi, K. Nonaka, A. P. Spork, N. Tibrewal, A. Goswami, P. Pahari, C. Ducho, J. Rohr, S. G. Van Lanen; Amalgamation of Nucleosides and Amino Acids in Antibiotic Biosynthesis: Discovery of an L-Threonine:Uridine-5′-Aldehyde Transaldolase; J. Am. Chem. Soc. 2012, 134, 18514-18517.
  46. M. Büschleb, M. Granitzka, D. Stalke, C. Ducho; A biomimetic domino reaction for the concise synthesis of capreomycidine and epicapreomycidine; Amino Acids 2012, 43, 2313-2328.
  47. R. B. Hamed, L. Henry, J. R. Gomez-Castellanos, J. Mecinović, C. Ducho, J. L. Sorensen, T. D. W. Claridge, C. J. Schofield; Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams; J. Am. Chem. Soc. 2012, 134, 471-479.
  48. A. P. Spork, D. Wiegmann, M. Granitzka, D. Stalke, C. Ducho; Stereoselective Synthesis of Uridine-Derived Nucleosyl Amino Acids; J. Org. Chem. 2011, 76, 10083-10098.
  49. C. Ducho; Ein Kaleidoskop der zeitgenössischen Organischen Chemie: die 46ste Bürgenstock-Konferenz; Angew. Chem. 2011, 123, 6829-6832; A Kaleidoscope of Contemporary Organic Chemistry: the 46th Bürgenstock Conference; Angew. Chem. Int. Ed. 2011, 50, 6697-6700. (Meeting Review)
  50. O. Ries, A. Ochmann, C. Ducho; Synthesis of N-Alkyl-N-hydroxy-guanidines: A Comparative Study Using Different Protecting Group Strategies; Synthesis 2011, 2357-2368. (Feature Article)
  51. R. B. Hamed, J. R. Gomez-Castellanos, A. Thalhammer, D. Harding, C. Ducho, T. D. W. Claridge, C. J. Schofield; Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases; Nat. Chem. 2011, 3, 365-371.
  52. C. Ducho; Konvergenz führt zum Erfolg: Totalsynthese des komplexen nicht-ribosomalen Peptids Polytheonamid B; Angew. Chem. 2010, 122, 5156-5158; Convergence Leads to Success: Total Synthesis of the Complex Nonribosomal Peptide Polytheonamide B; Angew. Chem. Int. Ed. 2010, 49, 5034-5036. (Highlight article)
  53. A. P. Spork, S. Koppermann, B. Dittrich, R. Herbst-Irmer, C. Ducho; Efficient synthesis of the core structure of muraymycin and caprazamycin nucleoside antibiotics based on a stereochemically revised sulfur ylide reaction; Tetrahedron: Asymmetry 2010, 21, 763-766.
  54. A. P. Spork, C. Ducho; Novel 5'-deoxy nucleosyl amino acid scaffolds for the synthesis of muraymycin analogues; Org. Biomol. Chem. 2010, 8, 2323-2326.
  55. R. B. Hamed, J. Mecinović, C. Ducho, T. D. W. Claridge, C. J. Schofield; Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles; Chem. Commun. 2010, 46, 1413-1415.
  56. A. Lemke, M. Büschleb, C. Ducho; Concise synthesis of both diastereomers of 3-hydroxy-L-arginine; Tetrahedron 2010, 66, 208-214. (Front cover)
  57. A. P. Spork, S. Koppermann, C. Ducho; Improved Convergent Synthesis of 5'-epi-Analogues of Muraymycin Nucleoside Antibiotics; Synlett 2009, 2503-2507.
  58. C. Ducho, R. B. Hamed, E. T. Batchelar, J. L. Sorensen, B. Odell, C. J. Schofield; Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis; Org. Biomol. Chem. 2009, 7, 2770-2779.
  59. C. Meier, N. Gisch, C. Ducho, J. Balzarini; CycloSaligenyl-di-d4TMP: Highly Loaded CycloSal-pronucleotides that Release Two Equivalents of Nucleotides and Leaving One Masking Unit; Antiviral Res. 2009, 82, A61.
  60. E. T. Batchelar, R. B. Hamed, C. Ducho, T. D. W. Claridge, M. J. Edelmann, B. Kessler, C. J. Schofield; Thioester Hydrolysis and C-C Bond Formation by Carboxymethylproline Synthase from the Crotonase Superfamily; Angew. Chem. 2008, 120, 9462-9465; Angew. Chem. Int. Ed. 2008, 47, 9322-9325.
  61. C. Ducho, U. Görbig, S. Jessel, N. Gisch, J. Balzarini, C. Meier; Bis-cycloSal-d4T-monophosphates: Drugs That Deliver Two Molecules of Bioactive Nucleotides; J. Med. Chem. 2007, 50, 1335-1346.
  62. C. Meier, C. Ducho, H. Jessen, D. Vukadinovic-Tenter, J. Balzarini; Second generation cycloSal-d4TMP pronucleotides bearing esterase-cleavable sites - the "trapping"-concept; Eur. J. Org. Chem. 2006, 197-206.
  63. C. Ducho, S. Jessel, N. Gisch, J. Balzarini, C. Meier; Novel cycloSal Nucleotides with Reduced Inhibitory Potency towards Human Butyrylcholinesterase; Nucleosides Nucleotides 2005, 24, 519-522.
  64. C. Meier, C. Ducho, H. Jessen, J. Balzarini; Esterase-cleavable cycloSal-pronucleotides - the trapping concept; Coll. Symp. Series 2005, 7, 105-113.
  65. C. Meier, C. Ducho, H. J. Jessen, J. Balzarini; Novel "lock-in" modified cycloSal nucleotides (II): Application of the AM- and the POM-group; Antiviral Res. 2005, 65, A27.
  66. C. Meier, C. Ducho, U. Görbig, R. Esnouf, J. Balzarini; Interaction of cycloSal-Pronucleotides with Cholinesterases from Different Origins. A Structure-Activity Relationship; J. Med. Chem. 2004, 47, 2839-2852.
  67. C. Meier, C. Ducho, J. Balzarini; Are cholinesterases inhibited by cycloSal nucleotides?; Antiviral Res. 2004, 62, A85.
  68. C. Ducho, S. Wendicke, U. Görbig, J. Balzarini, C. Meier; 3,5-Di-(tert-butyl)-6-fluoro-cycloSal-d4TMP - a pronucleotide with a considerably improved masking group; Eur. J. Org. Chem. 2003, 4786-4791.
  69. C. Ducho, J. Balzarini, C. Meier; Non-inhibition of Acetylcholinesterase by cycloSal Nucleotides; Nucleosides Nucleotides 2003, 22, 841-843.
  70. C. Ducho, J. Balzarini, C. Meier; Interaction of Cholinesterases with cycloSal Nucleotides; Antiviral Res. 2003, 57, A54.
  71. C. Meier, J. Renze, C. Ducho, J. Balzarini; cycloSal-d4TMP Pronucleotides - Structural Variations, Mechanistic Insights and Antiviral Activity; Curr. Top. Med. Chem. 2002, 2, 1111-1121. (Review)
  72. C. Ducho, J. Balzarini, L. Naesens, E. De Clercq, C. Meier; Aryl-substituted and Benzo-annulated cycloSal-derivatives of 2',3'-Dideoxy-2',3'-didehydrothymidine Monophosphate - Correlation of Structure, Hydrolysis Properties and Anti-HIV Activity; Antiviral Chem. Chemother. 2002, 13, 129-141.
  73. J. Renze, M. Plath, C. Ducho, J. Balzarini, E. De Clercq, C. Meier; Benzyl-functionalized cycloSal-d4T Monophosphates; Nucleosides Nucleotides 2001, 20, 931-934.
  74. J. Renze, M. Plath, C. Ducho, J. Balzarini, E. De Clercq, C. Meier; Hydrolysis Behaviour of Benzyl-functionalized cycloSal-d4TMPs; Antiviral Res. 2001, 50, A47.


  1. Isis Innovation, C. J. Schofield, R. B. Hamed, E. Batchelar, C. Ducho;   Methods for preparing substituted N-heterocyclic rings, especially trans-carboxymethyl-proline derivatives and analogs, via enzymatically carbon-carbon bond formation reaction in the presence of a crotonase superfamily protein or a homolog or variant for use in the synthesis of antibiotics; PCT Int. Appl. 2010, WO 2010046713.